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see also on this site NeuroIoTool(s)
multi electrode array users mailing list
“This is a scientific discussion group for researchers who use multi-electrode arrays to record and stimulate brain cells, in vitro or in vivo.”
http://groups.yahoo.com/group/mea-users/
Steve M. Potter, PhD, Administrator <spotter@gg.caltech.edu>
MEA Bibliography: http://www.caltech.edu/~pinelab/multielectrodeRefs.htm
Spring 2001
Implantable Electrodes and Computers in Brain
Karl Bohringer, Tom Daniel, Denise Denton, Chris Diorio, A.O. Dennis Willows
Zoology 498: (12 credits)
This team will work on an interdisciplinary project to link neuron-level and
behavioral studies of brain mechanisms using implantable electrode/computer
interfaces, designed with innovative electrical, and mechanical engineering
technology. Our long term goal is to develop fundamentally new technology to
implant computer electronics directly into brain. The team will work with the
extraordinarily large, individually identifiable brain cells of marine organisms
(especially nudibranch mollusks) as model systems, both in the laboratory and in
the field.
Students will learn to use intracellular recording devices in brain cells of
nearly intact animals, to label neurons with immunofluorescent dyes, observe
functional differences between neurons in laser scanning confocal microscopy,
develop skills in design of microelectromechanical devices (viz.,
microelectrodes) etched onto silicon microchips, along with control circuitry
and memory to record long-term neurophysiological data from freely behaving
organisms in their natural environment. For additional information, contact Karl
Bohringer.
Further description
Student Application Form
http://depts.washington.edu/fhl/apprentice.html#Bohringer
kevin warwick
had chip implanted in self
* Winter, J. O., Liu, T. Y., Korgel, B. A. & Schmidt, C. E. Recognitionmolecule directed interfacing between semiconductor quantum dots and nerve
cells. Advanced Materials, 13, 1673 - 1677, (2001).
http://www.nature.com/nsu/011115/011115-7.html
developed a protein that sticks to neurons and semiconductors to make electrical
connection better
* Zeck, G. & Fromherz, P.Noninvasive neuroelectronic interfacing withsynaptically connected snail neurons on a semiconductor chip. Proceedings of the
National Academy of Sciences, 98, 10457 - 10462, (2001).
http://www.nature.com/nsu/010830/010830-7.html
used micro fenceposts to keep the neuron from moving around on the chip as it
grows connections
John Chapin of the Hahnemann School of Medicine, Philadelphia, Pennsylvania and
colleagues, in the July issue of Nature Neuroscience (99).
http://www.nature.com/nsu/990624/990624-5.html
gave rats control of simple robot arm through implants in motor cortex and
thalamus. studied signals in these areas to make the arm work intuitively for
the rats (rats had been trained to use real world controls for arm, so he found
the firing patterns used for operating these controls and attuned robot arm to
these patterns)
A device developed at Georgia Tech is helping Ray, the victim of a massivestroke that left him mute and almost completely paralyzed, communicate through a
computer using the tiny electrical impulses generated by his brain.
Dr. Philip R. Kennedy, a clinical assistant professor of neurology at Emory
University in Atlanta, developed and patented the “neurotrophic electrode” in
the mid-1980s while working as a neural prosthetics researcher at Tech. His work
capitalizes on the basic fact that the act of thinking prompts physical activity
in the brain in the form of electrical impulses. Implanted into a patient’s
brain, the electrode detects and captures those electrical signals, which are
processed by customized microelectronics and software applications to move a
cursor and select icons on the screen. In effect, the brain’s neural signals
become a computer mouse.
http://www.gtri.gatech.edu/rh-sf99/brain.html
the dobelle group
www.artificialvision.com
cortical implants in two blind volunteers that have stayed in for 20 years
without infection or other problems!
http://www.artificialvision.com/vision/asaio1.html
daniel dilorenzo
won a prize at MIT? in 1999, now at Utah in residency
made a device for allowing prosthetic touch
couldn’t find info on the device itself
Miguel Nicolel is at Duke
John Chapin, State University of New York Health Science Center
Mandayam Srinivasan, MIT?
other co-authors of the paper were, from Duke, Johan Wessberg, Christopher
Stambaugh, Jerald Kralik, Pamela Beck and Mark Laubach; and from MIT?, Jung Kim
and James Biggs.
Nov. 16, 2000, Nature
MONKEYS? CONTROL? A ROBOT? ARM? VIA? BRAIN SIGNALS? (remote)
http://www.eas.asu.edu/~bme/pages/faculty/schwartz.html
We are developing the technology to record chronically from many electrodes
implanted in cerebral cortex
….
A second project just begun, is a project to implant chronic multiprobes in the
basal ganglia. These will be used to record activity from many cells that are
dysfunctional in Parkinson’s disease.
very interested in processing and representations
Utah http://www.bioen.utah.edu/cni Neural Interfaces
Utah Electrode Array (UEA?)
-Develping next generation cochlear and brainstem implants (Badi, Hillman et al)
-Making a visual cortical implant
People list:
Center’s Director Richard A. Normann, Ph.D.
Center’s Co-director Arunkumar N. Badi, M.D. , Ph.D.
Graduate Students
Almut Branner, Dipl.-Ing. Shane Guillory Mark Lehmkuhle Shy Shoham Dave Warren, M.S.
Collaborators
Josef Ammermuller, Ph.D. Eduardo Fernandez, M.D. Todd Hillman, M.D. Tom Kertesz, M.D. Clough Shelton, M.D.
Richard Stein, Ph.D.
Undergraduate Assistants
Jeff McCann? Victor Sevastyanenko Matt Sinclair Michelle Krouge Elizabeth Newren Eric Nielsen
Technician
YanPing? Zhang, B.S.
keep exploring the links on this one
ADAM CURTIS
Adam Curtis is at the Centre for Cell Engineering, IBLS?, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
e-mail: a.curtis@bio.gla.ac.uk
wrote an article in Nature:
But secure, long-term positioning of neurites (on a scale of days to weeks) has been achieved2, with lines of neurons immobilized using the protein laminin. Maher et al.3 have also grown cells in deep pits, and recorded data from them. An alternative to network growing has also been tried. In an earlier, seminal experiment, Syed and collegues4 reconstructed neuronal circuits by delicate hand surgery and managed to rebuild a working circuit. But they did not explore modified circuits or the effects of changes in the message.
Now Merz and Fromherz1 have built on the results of such experiments, and have obtained well-defined, if very small, stable networks of cultured neurons from the pond snail Lymnaea stagnalis. Using microfabrication techniques, they etched a series of pits and grooves in a polyester surface on a silicon substrate (Fig. 1a). The design traps the cell bodies but allows neurites to grow along the grooves.
…
In fact, my own group has recently invented a manipulable extracellular electrode array5 that can be rapidly moved from site to site.
…
Judith Wilkinson (quoted in ref. 6) has applied graph and tiling theory to design networks that should be able to propagate and compare messages
…
References
1.
Merz, M. & Fromherz, P. Adv. Mater. 14, 141-144 (2002). Article ISI
2.
Lauer, L., Klein, C. & Offenhauesser, A. Biomaterials 22, 1925-1932 (2001). Article PubMed ISI
3.
Maher, M. P. et al. Cell. Eng. 37, 110-118 (1999).
4.
Syed, N. I., Bulloch, A. G. M. & Lukowiak, K. Science 250, 282-285 (1990). PubMed ISI
5.
Sandison, M., Curtis, A. S. G. & Wilkinson, C. D. W. J. Neurosci. Methods 114, 63-71 (2002). PubMed ISI
6.
Wilkinson, C. D. W. & Curtis, A. S. G. Physics World 12, 45-48 (1999). ISI
interested in MEAs?, organized artificial cultures of neurons
Bruce Wheeler <bwheeler@uiuc.edu>
Professor of Electrical and Computer Engineering, the Beckman
Institute, Bioengineering and the Neuroscience Program
University of Illinois at Urbana-Champaign
2351 Beckman Institute, 405 N. Mathews Ave., Urbana IL 61801
217-333-3236; fax 217-244-5180; bwheeler@uiuc.edu
More people at brown:
CS: Michael J. Black
Elie Bienenstock, Depts. of Applied Math and Neuroscience, Brown University.
Yun Gao, Division of Applied Math, Brown University.
Wei Wu, Division of Applied Math, Brown University.
Mijail Serruya, Department of Neuroscience, Brown University.
Frank Wood, Department of Computer Science, Brown University.
# Miguel A. L. Nicolelis's Lab (Duke U) (they are very un- MeatBall:LynxFriendly? !)
Andy Schwartz at the Univeristy of Pittsburgh: http://motorlab.neurobio.pitt.edu/
Krishna Shenoy at Stanford: http://www.stanford.edu/~shenoy/group.html
